IGF-1 LR3
Long R3 Variant — Extended Half-Life IGF-1 Analog
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a recombinant analog of human IGF-1 with an N-terminal 13 amino acid extension and a glutamic acid substitution at position 3. These modifications significantly reduce binding to IGF-binding proteins (IGFBPs), resulting in a substantially extended half-life compared to native IGF-1. This makes it a highly useful research tool for studying IGF-1 receptor (IGF-1R) signaling, cellular proliferation, differentiation, and survival pathways in cell culture and preclinical models without the confounding effects of IGFBP sequestration.
Product Specifications
Store lyophilized at -20°C. Reconstituted solution stable at 4°C for up to 5 days. Avoid repeated freeze-thaw cycles.
≥98% by HPLC
Lyophilized Powder
Research Notes
Mechanism of Action
Binds IGF-1R with high affinity, activating PI3K/Akt and MAPK/ERK signaling cascades. The LR3 modification reduces IGFBP binding by >1000-fold, extending biological activity duration in research systems. Widely used as a positive control in IGF-1R signaling studies and cell proliferation assays.
Research Use Only. This product is intended solely for in-vitro research and laboratory use by qualified researchers. It is not approved for human or animal consumption, therapeutic use, or diagnostic application. By purchasing, you confirm compliance with all applicable laws and regulations.
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